AI-Assisted Hypothesis Generation to Address Challenges in Cardiotoxicity Research: Simulation Study Using ChatGPT With GPT-4o

Yilan Li   ^{1 *} , MD, PhD ;   Tianshu Gu   ^{2 *} , MD, MS ;   Chengyuan Yang   ³ , MD, MS ;   Minghui Li   ² , PhD ;   Congyi Wang   ⁴ , MD, PhD ;   Lan Yao   ^{3, 5} , PhD ;   Weikuan Gu   ^{3, 6, 7} , PhD ;   DianJun Sun   ⁸ , MD, PhD

¹ The Second Affiliated Hospital of Harbin Medical University, Harbin, China

² Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Memphis, TN, United States

³ Department of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Centre, Memphis, TN, United States

⁴ Diabetes Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Doha, Qatar

⁵ College of Health Management, Harbin Medical University, Harbin, China

⁶ Lt. Col. Luke Weathers, Jr. VA Medical Center, Memphis, TN, United States

⁷ Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, United States

⁸ The Second Affiliated Hospital of Harbin Medical University, Centre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Key Laboratory of Etiologic Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health, Harbin, China

*these authors contributed equally